› 2rvm

Solution NMR

Solution structure of the chromodomain of HP1alpha with the phosphorylated N-terminal tail

Released:
DOI: 10.2210/pdb2rvm/pdb
PDB entry 2rvm coloured by chain, ensemble of 20 models, front view.
PDB entry 2rvm coloured by chain, ensemble of 20 models, side view.
PDB entry 2rvm coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Extended string-like binding of the phosphorylated HP1α N-terminal tail to the lysine 9-methylated histone H3 tail.
Shimojo H, Kawaguchi A, Oda T, Hashiguchi N, Omori S, Moritsugu K, Kidera A, Hiragami-Hamada K, Nakayama J, Sato M, Nishimura Y
Sci Rep 6 22527 (2016)
PMID: 26934956

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178897 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chromobox protein homolog 5 Chain: A
Molecule details ›
Chain: A
Length: 83 amino acids
Theoretical weight: 10.17 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q61686 (Residues: 1-80; Coverage: 42%)
Gene names: Cbx5, Hp1a
Sequence domains: Chromo (CHRromatin Organisation MOdifier) domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SEP 4 x SEP

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 94%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Application of NMR to studies of intrinsically disordered proteins.
Gibbs et al. (2017)
4 more

1 mention without citation

Extended string-like binding of the phosphorylated HP1α N-terminal tail to the lysine 9-methylated histone H3 tail.
Shimojo et al. (2016)