› 2rn8

Solution NMR

NMR structure note: murine Itk SH3 domain

Released:
DOI: 10.2210/pdb2rn8/pdb
PDB entry 2rn8 coloured by chain, ensemble of 20 models, front view.
PDB entry 2rn8 coloured by chain, ensemble of 20 models, side view.
PDB entry 2rn8 coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Entry author: Severin AJ

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169911 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ITK/TSK Chain: A
Molecule details ›
Chain: A
Length: 64 amino acids
Theoretical weight: 7.47 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q03526 (Residues: 177-238; Coverage: 10%)
Gene names: Emt, Itk, Tlk, Tsk
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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