› 2rjc

X-ray diffraction
2Å resolution

Crystal structure of L3MBTL1 protein in complex with MES

Released:
DOI: 10.2210/pdb2rjc/pdb
PDB entry 2rjc coloured by chain, front view.
PDB entry 2rjc coloured by chain, side view.
PDB entry 2rjc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
L3MBTL1 recognition of mono- and dimethylated histones.
Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH
Nat Struct Mol Biol 14 1229-30 (2007)
PMID: 18026117

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195224 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lethal(3)malignant brain tumor-like protein 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 331 amino acids
Theoretical weight: 37.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y468 (Residues: 268-598; Coverage: 39%)
Gene names: KIAA0681, L3MBT, L3MBTL, L3MBTL1
Sequence domains: mbt repeat
Structure domains: SH3 type barrels.

Ligands and Environments

2 bound ligands:
Ligand SO4 5 x SO4
Ligand MES 6 x MES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ DW
Spacegroup: P21
Unit cell:
a: 63.548Å b: 108.784Å c: 90.348Å
α: 90° β: 90.91° γ: 90°
R-values:
R R work R free
0.197 0.195 0.241
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

57 review citations

Double-strand break repair: 53BP1 comes into focus.
Panier et al. (2014)
56 more

1 mention without citation

Small-molecule ligands of methyl-lysine binding proteins.
Herold et al. (2011)