› 2r2p

X-ray diffraction
2.4Å resolution

Kinase domain of human ephrin type-A receptor 5 (EphA5)

Released:
DOI: 10.2210/pdb2r2p/pdb
PDB entry 2r2p coloured by chain, front view.
PDB entry 2r2p coloured by chain, side view.
PDB entry 2r2p coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Walker JR, Cuerrier D, Butler-Cole C, Weigelt J, Arrowsmith CH, Edwards AM, Bochkarev A, Dhe-Paganon S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157089 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 5 Chain: A
Molecule details ›
Chain: A
Length: 295 amino acids
Theoretical weight: 33.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P54756 (Residues: 653-939; Coverage: 28%)
Gene names: BSK, EHK1, EPHA5, HEK7, TYRO4
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P6522
Unit cell:
a: 80.085Å b: 80.085Å c: 169.237Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.199 0.283
Expression system: Escherichia coli BL21(DE3)

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