› 2r16

X-ray diffraction
1.04Å resolution

Crystal Structure of bovine neurexin 1 alpha LNS/LG domain 4 (with no splice insert)

Released:
DOI: 10.2210/pdb2r16/pdb
PDB entry 2r16 coloured by chain, front view.
PDB entry 2r16 coloured by chain, side view.
PDB entry 2r16 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Regulation of neurexin 1beta tertiary structure and ligand binding through alternative splicing.
Shen KC, Kuczynska DA, Wu IJ, Murray BH, Sheckler LR, Rudenko G
Structure 16 422-31 (2008)
PMID: 18334217

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173308 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurexin-1 Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 20.54 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q28146 (Residues: 737-805, 816-925; Coverage: 12%)
Gene name: NRXN1
Sequence domains: Laminin G domain
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P63
Unit cell:
a: 90.322Å b: 90.322Å c: 39.624Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.148 0.146 0.165
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Neuroligins and neurexins link synaptic function to cognitive disease.
Südhof TC. (2008)
10 more

7 mentions without citation

The crystal structure of the α-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function.
Miller et al. (2011)
6 more