› 2qmr

X-ray diffraction
3Å resolution

Karyopherin beta2/transportin

Released:
DOI: 10.2210/pdb2qmr/pdb
PDB entry 2qmr coloured by chain, front view.
PDB entry 2qmr coloured by chain, side view.
PDB entry 2qmr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational heterogeneity of karyopherin beta2 is segmental.
Cansizoglu AE, Chook YM
Structure 15 1431-41 (2007)
PMID: 17997969

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187824 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transportin-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 890 amino acids
Theoretical weight: 101.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92973 (Residues: 9-898; Coverage: 99%)
Gene names: KPNB2, MIP1, TNPO1, TRN
Sequence domains:
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 129.338Å b: 168.892Å c: 140.958Å
α: 90° β: 93.18° γ: 90°
R-values:
R R work R free
0.262 0.261 0.286
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Recognition of nuclear targeting signals by Karyopherin-β proteins.
Xu et al. (2010)
5 more

9 mentions without citation

Karyopherin-mediated nucleocytoplasmic transport.
Wing et al. (2022)
8 more