› 2qjf

X-ray diffraction
2.2Å resolution

Crystal structure of ATP-sulfurylase domain of human PAPS synthetase 1

Released:
DOI: 10.2210/pdb2qjf/pdb
PDB entry 2qjf coloured by chain, front view.
PDB entry 2qjf coloured by chain, side view.
PDB entry 2qjf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Sekulic N, Lavie A

Function and Biology Details

Reactions catalysed: 
ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate
ATP + sulfate = diphosphate + adenylyl sulfate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128876 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 405 amino acids
Theoretical weight: 46.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43252 (Residues: 220-624; Coverage: 65%)
Gene names: ATPSK1, PAPSS, PAPSS1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand K 2 x K
Ligand ADX 2 x ADX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 63.1Å b: 99.9Å c: 75.9Å
α: 90° β: 113° γ: 90°
R-values:
R R work R free
0.173 0.168 0.225
Expression system: Escherichia coli

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