› 2pmn

X-ray diffraction
2.8Å resolution

Crystal structure of PfPK7 in complex with an ATP-site inhibitor

Released:
DOI: 10.2210/pdb2pmn/pdb
PDB entry 2pmn coloured by chain, front view.
PDB entry 2pmn coloured by chain, side view.
PDB entry 2pmn coloured by chain, top view.
Source organism: Plasmodium falciparum
Primary publication:
Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design.
Merckx A, Echalier A, Langford K, Sicard A, Langsley G, Joore J, Doerig C, Noble M, Endicott J
Structure 16 228-38 (2008)
PMID: 18275814

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182219 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
mitogen-activated protein kinase kinase Chain: X
Molecule details ›
Chain: X
Length: 348 amino acids
Theoretical weight: 41.43 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q7YTF7 (Residues: 1-343; Coverage: 100%)
Gene name: PF3D7_0213400
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand K51 1 x K51
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C2221
Unit cell:
a: 73.406Å b: 82.084Å c: 138.962Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.219 0.296
Expression system: Escherichia coli BL21

Quick links

Citations

11 review citations

Protein kinases of malaria parasites: an update.
Doerig et al. (2008)
10 more

4 mentions without citation

Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities.
Arendse et al. (2021)
3 more