› 2pm4

X-ray diffraction
1.95Å resolution

Human alpha-defensin 1 (multiple Arg->Lys mutant)

Released:
DOI: 10.2210/pdb2pm4/pdb
PDB entry 2pm4 coloured by chain, front view.
PDB entry 2pm4 coloured by chain, side view.
PDB entry 2pm4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs.
Zou G, de Leeuw E, Li C, Pazgier M, Li C, Zeng P, Lu WY, Lubkowski J, Lu W
J Biol Chem 282 19653-65 (2007)
PMID: 17452329

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157841 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutrophil defensin 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 30 amino acids
Theoretical weight: 3.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P59666 (Residues: 66-94; Coverage: 39%)
Gene names: DEF3, DEFA3
Sequence domains: Mammalian defensin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P4222
Unit cell:
a: 41.383Å b: 41.383Å c: 97.165Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.192 0.249
Expression system: Escherichia coli

Quick links

Citations

11 review citations

α-Defensins in human innate immunity.
Lehrer et al. (2012)
10 more

2 mentions without citation

Comparative genomics and evolution of the alpha-defensin multigene family in primates.
Das et al. (2010)
1 more