› 2pfr

X-ray diffraction
1.92Å resolution

Human N-acetyltransferase 2

Released:
DOI: 10.2210/pdb2pfr/pdb
PDB entry 2pfr coloured by chain, front view.
PDB entry 2pfr coloured by chain, side view.
PDB entry 2pfr coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tempel W, Wu H, Dombrovski L, Loppnau P, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Grant DM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-145726 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arylamine N-acetyltransferase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 294 amino acids
Theoretical weight: 33.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11245 (Residues: 2-290; Coverage: 100%)
Gene names: AAC2, NAT2
Sequence domains: N-acetyltransferase
Structure domains: Arylamine N-acetyltransferase fold

Ligands and Environments


Cofactor: Ligand COA 2 x COA
2 bound ligands:
Ligand SO4 7 x SO4
Ligand UNX 27 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E, null
Spacegroup: P43212
Unit cell:
a: 130.063Å b: 130.063Å c: 111.23Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.209 0.245
Expression system: Escherichia coli

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