› 2pa5

X-ray diffraction
1.6Å resolution

Crystal structure of human protein tyrosine phosphatase PTPN9

Released:
DOI: 10.2210/pdb2pa5/pdb
PDB entry 2pa5 coloured by chain, front view.
PDB entry 2pa5 coloured by chain, side view.
PDB entry 2pa5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S
Cell 136 352-63 (2009)
PMID: 19167335

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155050 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 9 Chains: A, B
Molecule details ›
Chains: A, B
Length: 314 amino acids
Theoretical weight: 36.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43378 (Residues: 277-582; Coverage: 52%)
Gene name: PTPN9
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

3 bound ligands:
Ligand CL 4 x CL
Ligand SCN 1 x SCN
Ligand EDO 5 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P1
Unit cell:
a: 39.965Å b: 57.427Å c: 66.446Å
α: 77.44° β: 78.22° γ: 80.41°
R-values:
R R work R free
0.157 0.156 0.188
Expression system: Escherichia coli

Quick links

Citations

59 review citations

Inside the human cancer tyrosine phosphatome.
Julien et al. (2011)
58 more

4 mentions without citation

A highly selective and potent PTP-MEG2 inhibitor with therapeutic potential for type 2 diabetes.
Zhang et al. (2012)
3 more