› 2p9w

X-ray diffraction
1.35Å resolution

Crystal Structure of the Major Malassezia sympodialis Allergen Mala s 1

Released:
DOI: 10.2210/pdb2p9w/pdb
PDB entry 2p9w coloured by chain, front view.
PDB entry 2p9w coloured by chain, side view.
PDB entry 2p9w coloured by chain, top view.
Source organism: Malassezia sympodialis
Primary publication:
Crystal structure of the major Malassezia sympodialis allergen Mala s 1 reveals a beta-propeller fold: a novel fold among allergens.
Vilhelmsson M, Zargari A, Crameri R, Rasool O, Achour A, Scheynius A, Hallberg BM
J Mol Biol 369 1079-86 (2007)
PMID: 17481656

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180496 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mal s 1 allergenic protein Chain: A
Molecule details ›
Chain: A
Length: 334 amino acids
Theoretical weight: 36.87 KDa
Source organism: Malassezia sympodialis
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q6WIF3 (Residues: 1-216; Coverage: 100%)

Ligands and Environments

3 bound ligands:
Ligand SO4 5 x SO4
Ligand CL 1 x CL
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: P21212
Unit cell:
a: 44.48Å b: 164Å c: 50.68Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.139 0.139 0.153
Expression system: Escherichia coli BL21

Quick links

Citations

6 review citations

The Malassezia genus in skin and systemic diseases.
Gaitanis et al. (2012)
5 more

3 mentions without citation

Relevant B cell epitopes in allergic disease.
Pomés A. (2010)
2 more