› 2ozf

X-ray diffraction
1.5Å resolution

The crystal structure of the 2nd PDZ domain of the human NHERF-1 (SLC9A3R1)

Released:
DOI: 10.2210/pdb2ozf/pdb
PDB entry 2ozf coloured by chain, front view.
PDB entry 2ozf coloured by chain, side view.
PDB entry 2ozf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Phillips C, Papagrigoriou E, Gileadi C, Fedorov O, Elkins J, Berridge G, Turnbull AP, Gileadi O, Schoch G, Smee C, Bray J, Savitsky P, Uppenberg J, von Delft F, Gorrec F, Umeano C, Salah E, Colebrook S, Weigelt J, Arrowsmith CH, Edwards A, Sundstrom M, Doyle DA, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127084 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Chain: A
Molecule details ›
Chain: A
Length: 92 amino acids
Theoretical weight: 9.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14745 (Residues: 150-235; Coverage: 24%)
Gene names: NHERF, NHERF1, SLC9A3R1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: I222
Unit cell:
a: 43.304Å b: 54.715Å c: 96.724Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.17 0.211
Expression system: Escherichia coli BL21(DE3)

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