› 2osg

Solution NMR

Solution Structure and Binding Property of the Domain-swapped Dimer of ZO2PDZ2

Released:
DOI: 10.2210/pdb2osg/pdb
PDB entry 2osg coloured by chain, ensemble of 20 models, front view.
PDB entry 2osg coloured by chain, ensemble of 20 models, side view.
PDB entry 2osg coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Domain-swapped dimerization of the second PDZ domain of ZO2 may provide a structural basis for the polymerization of claudins.
Wu J, Yang Y, Zhang J, Ji P, Du W, Jiang P, Xie D, Huang H, Wu M, Zhang G, Wu J, Shi Y
J Biol Chem 282 35988-99 (2007)
PMID: 17897942

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193697 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tight junction protein ZO-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 83 amino acids
Theoretical weight: 9.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UDY2 (Residues: 306-385; Coverage: 7%)
Gene names: TJP2, X104, ZO2
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing, molecular dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

The Par3/Par6/aPKC complex and epithelial cell polarity.
Chen et al. (2013)
7 more

2 mentions without citation

Structural Determinants of Misfolding in Multidomain Proteins.
Tian et al. (2016)
1 more