› 2orx

X-ray diffraction
2.4Å resolution

Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin

Released:
DOI: 10.2210/pdb2orx/pdb
PDB entry 2orx coloured by chain, front view.
PDB entry 2orx coloured by chain, side view.
PDB entry 2orx coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis for ligand and heparin binding to neuropilin B domains.
Vander Kooi CW, Jusino MA, Perman B, Neau DB, Bellamy HD, Leahy DJ
Proc Natl Acad Sci U S A 104 6152-7 (2007)
PMID: 17405859

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193032 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuropilin-1 Chain: A
Molecule details ›
Chain: A
Length: 314 amino acids
Theoretical weight: 35.73 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9QWJ9 (Residues: 273-586; Coverage: 35%)
Gene name: Nrp1
Sequence domains: F5/8 type C domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CAMD BEAMLINE GCPCC
Spacegroup: P212121
Unit cell:
a: 38.094Å b: 92.221Å c: 120.115Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.201 0.252
Expression system: Escherichia coli

Quick links

Citations

43 review citations

Signal transduction by vascular endothelial growth factor receptors.
Koch et al. (2011)
42 more

2 mentions without citation

Structural basis for ligand and heparin binding to neuropilin B domains.
Vander Kooi et al. (2007)
1 more