› 2n1n

Solution NMR

Solution structure of VSTx1

Released:
DOI: 10.2210/pdb2n1n/pdb
PDB entry 2n1n coloured by chain, ensemble of 20 models, front view.
PDB entry 2n1n coloured by chain, ensemble of 20 models, side view.
PDB entry 2n1n coloured by chain, ensemble of 20 models, top view.
Source organism: Grammostola rosea
Primary publication:
Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels.
Lau CH, King GF, Mobli M
Sci Rep 6 34333
PMID: 27677715

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158159 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kappa-theraphotoxin-Gr3a Chain: A
Molecule details ›
Chain: A
Length: 35 amino acids
Theoretical weight: 4.1 KDa
Source organism: Grammostola rosea
Expression system: Escherichia coli
UniProt:
  • Canonical: P60980 (Residues: 30-63; Coverage: 81%)
Sequence domains: Ion channel inhibitory toxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 95%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Venom-derived peptide inhibitors of voltage-gated potassium channels.
Norton et al. (2017)
4 more

3 mentions without citation

Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels.
Lau et al. (2016)
2 more