› 2mkj

Solution NMR

Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in free state

Released:
DOI: 10.2210/pdb2mkj/pdb
PDB entry 2mkj coloured by chain, ensemble of 20 models, front view.
PDB entry 2mkj coloured by chain, ensemble of 20 models, side view.
PDB entry 2mkj coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins.
Afroz T, Skrisovska L, Belloc E, Guillén-Boixet J, Méndez R, Allain FH
Genes Dev 28 1498-514 (2014)
PMID: 24990967

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172643 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytoplasmic polyadenylation element-binding protein 4 Chain: A
Molecule details ›
Chain: A
Length: 203 amino acids
Theoretical weight: 22.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q17RY0 (Residues: 460-662; Coverage: 28%)
Gene names: CPEB4, KIAA1673
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 68%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Cellular and System Biology of Memory: Timing, Molecules, and Beyond.
Korte et al. (2016)
10 more

2 mentions without citation

Role of CPEB3 protein in learning and memory: new insights from synaptic plasticity.
Qu et al. (2020)
1 more