› 2mjn

Solution NMR

Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1

Released:
DOI: 10.2210/pdb2mjn/pdb
PDB entry 2mjn coloured by chain, ensemble of 10 models, front view.
PDB entry 2mjn coloured by chain, ensemble of 10 models, side view.
PDB entry 2mjn coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1.
Wang I, Hennig J, Jagtap PK, Sonntag M, Valcárcel J, Sattler M
Nucleic Acids Res 42 5949-66 (2014)
PMID: 24682828

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152017 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytotoxic granule associated RNA binding protein TIA1 Chain: A
Molecule details ›
Chain: A
Length: 186 amino acids
Theoretical weight: 20.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31483 (Residues: 105-285; Coverage: 47%)
Gene name: TIA1
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli

Quick links

Citations

15 review citations

RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate.
García-Mauriño et al. (2017)
14 more

9 mentions without citation

RNA recognition and stress granule formation by TIA proteins.
Waris et al. (2014)
8 more