› 2l4z

Solution NMR

NMR structure of fusion of CtIP (641-685) to LMO4-LIM1 (18-82)

Released:
DOI: 10.2210/pdb2l4z/pdb
PDB entry 2l4z coloured by chain, ensemble of 20 models, front view.
PDB entry 2l4z coloured by chain, ensemble of 20 models, side view.
PDB entry 2l4z coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of the interaction of the breast cancer oncogene LMO4 with the tumour suppressor CtIP/RBBP8.
Stokes PH, Liew CW, Kwan AH, Foo P, Barker HE, Djamirze A, O'Reilly V, Visvader JE, Mackay JP, Matthews JM
J Mol Biol 425 1101-10 (2013)
PMID: 23353824

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158510 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
LIM domain transcription factor LMO4 Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 13.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61969 (Residues: 18-82; Coverage: 39%)
Gene name: Lmo4
Sequence domains: LIM domain
Structure domains: Cysteine Rich Protein

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics
Expression system: Escherichia coli BL21(DE3)

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Citations

6 citation in other articles

Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci.
Han et al. (2016)
5 more