› 2kv3

Solution NMR

Human Regenerating Gene Type IV (REG IV) PROTEIN, P91S mutant

Released:
DOI: 10.2210/pdb2kv3/pdb
PDB entry 2kv3 coloured by chain, ensemble of 20 models, front view.
PDB entry 2kv3 coloured by chain, ensemble of 20 models, side view.
PDB entry 2kv3 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites.
Ho MR, Lou YC, Wei SY, Luo SC, Lin WC, Lyu PC, Chen C
J Mol Biol 402 682-95 (2010)
PMID: 20692269

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189849 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Regenerating islet-derived protein 4 Chain: A
Molecule details ›
Chain: A
Length: 131 amino acids
Theoretical weight: 15.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BYZ8 (Residues: 29-158; Coverage: 96%)
Gene names: GISP, REG4, RELP
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli

Quick links

Citations

6 review citations

"Rules of Engagement" of Protein-Glycoconjugate Interactions: A Molecular View Achievable by using NMR Spectroscopy and Molecular Modeling.
Marchetti et al. (2016)
5 more

2 mentions without citation

Four Decades After the Discovery of Regenerating Islet-Derived (Reg) Proteins: Current Understanding and Challenges.
Chen et al. (2019)
1 more