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Solution NMR

Solution structure of CA150 FF1 domain and FF1-FF2 interdomain linker

Released:
DOI: 10.2210/pdb2kis/pdb
PDB entry 2kis coloured by chain, ensemble of 7 models, front view.
PDB entry 2kis coloured by chain, ensemble of 7 models, side view.
PDB entry 2kis coloured by chain, ensemble of 7 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays.
Murphy JM, Hansen DF, Wiesner S, Muhandiram DR, Borg M, Smith MJ, Sicheri F, Kay LE, Forman-Kay JD, Pawson T
J Mol Biol 393 409-24 (2009)
PMID: 19715701

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127124 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription elongation regulator 1 Chain: A
Molecule details ›
Chain: A
Length: 71 amino acids
Theoretical weight: 8.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14776 (Residues: 659-724; Coverage: 6%)
Gene names: CA150, TAF2S, TCERG1
Sequence domains: FF domain
Structure domains: FF domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 81%
Refinement method: simulated annealing, distance geometry
Expression system: Escherichia coli

Quick links

Citations

5 citation in other articles

Specific interaction of the transcription elongation regulator TCERG1 with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5, and Ser7 within the carboxyl-terminal domain repeat.
Liu et al. (2013)
4 more

2 mentions without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)
1 more