› 2jul

Solution NMR

NMR Structure of DREAM

Released:
DOI: 10.2210/pdb2jul/pdb
PDB entry 2jul coloured by chain, ensemble of 15 models, front view.
PDB entry 2jul coloured by chain, ensemble of 15 models, side view.
PDB entry 2jul coloured by chain, ensemble of 15 models, top view.
Source organism: Mus musculus
Primary publication:
NMR structure of DREAM: Implications for Ca(2+)-dependent DNA binding and protein dimerization.
Lusin JD, Vanarotti M, Li C, Valiveti A, Ames JB
Biochemistry 47 2252-64 (2008)
PMID: 18201103

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193045 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calsenilin Chain: A
Molecule details ›
Chain: A
Length: 256 amino acids
Theoretical weight: 29.5 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9QXT8 (Residues: 1-256; Coverage: 100%)
Gene names: Csen, Dream, Kchip3, Kcnip3
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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Citations

12 review citations

Mechanisms of specificity in neuronal activity-regulated gene transcription.
Lyons et al. (2011)
11 more

7 mentions without citation

Pharmacological Approaches for the Modulation of the Potassium Channel KV4.x and KChIPs.
Cercós et al. (2021)
6 more