› 2js0

Solution NMR

Solution structure of second SH3 domain of adaptor Nck

Released:
DOI: 10.2210/pdb2js0/pdb
PDB entry 2js0 coloured by chain, ensemble of 20 models, front view.
PDB entry 2js0 coloured by chain, ensemble of 20 models, side view.
PDB entry 2js0 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Specificity determinants of a novel Nck interaction with the juxtamembrane domain of the epidermal growth factor receptor.
Hake MJ, Choowongkomon K, Kostenko O, Carlin CR, Sönnichsen FD
Biochemistry 47 3096-108 (2008)
PMID: 18269246

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147690 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SH2/SH3 adapter protein NCK1 Chain: A
Molecule details ›
Chain: A
Length: 61 amino acids
Theoretical weight: 6.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P16333 (Residues: 107-165; Coverage: 16%)
Gene names: NCK, NCK1
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Calmodulin-mediated regulation of the epidermal growth factor receptor.
Sánchez-González et al. (2010)
12 other articles

3 mentions without citation

The Disordered Cellular Multi-Tasker WIP and Its Protein-Protein Interactions: A Structural View.
Sokolik et al. (2020)
2 more