› 2jby

X-ray diffraction
2.41Å resolution

A viral protein unexpectedly mimics the structure and function of pro- survival Bcl-2

Released:
DOI: 10.2210/pdb2jby/pdb
PDB entry 2jby coloured by chain, front view.
PDB entry 2jby coloured by chain, side view.
PDB entry 2jby coloured by chain, top view.
Source organisms:
Primary publication:
A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.
Kvansakul M, van Delft MF, Lee EF, Gulbis JM, Fairlie WD, Huang DC, Colman PM
Mol Cell 25 933-42 (2007)
PMID: 17386268

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172523 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Apoptosis regulator M11L Chain: A
Molecule details ›
Chain: A
Length: 145 amino acids
Theoretical weight: 16.6 KDa
Source organism: Myxoma virus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q85295 (Residues: 2-132; Coverage: 79%)
Gene names: M11L, m011L
Sequence domains: Apoptosis regulator M11L like
Structure domains: Blc2-like
Bcl-2 homologous antagonist/killer Chain: B
Molecule details ›
Chain: B
Length: 26 amino acids
Theoretical weight: 2.88 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q16611 (Residues: 67-92; Coverage: 12%)
Gene names: BAK, BAK1, BCL2L7, CDN1

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P41212
Unit cell:
a: 69.187Å b: 69.187Å c: 120.601Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.288 0.287 0.292
Expression systems:
  • Escherichia coli BL21
  • Not provided

Quick links

Citations

27 review citations

The BCL-2 protein family: opposing activities that mediate cell death.
Youle et al. (2008)
26 more

8 mentions without citation

How vaccinia virus has evolved to subvert the host immune response.
Bahar et al. (2011)
7 more