› 2ja3

X-ray diffraction
3.05Å resolution

Cytoplasmic Domain of the Human Chloride Transporter ClC-5 in complex with ADP

Released:
DOI: 10.2210/pdb2ja3/pdb
PDB entry 2ja3 coloured by chain, front view.
PDB entry 2ja3 coloured by chain, side view.
PDB entry 2ja3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5.
Meyer S, Savaresi S, Forster IC, Dutzler R
Nat Struct Mol Biol 14 60-7 (2007)
PMID: 17195847

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156416 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
H(+)/Cl(-) exchange transporter 5 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 185 amino acids
Theoretical weight: 21.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51795 (Residues: 640-816; Coverage: 22%)
Gene names: CLCK2, CLCN5
Sequence domains: CBS domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ADP 6 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21212
Unit cell:
a: 126.567Å b: 149.308Å c: 81.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.28 0.278 0.317
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

31 review citations

CLC chloride channels and transporters: from genes to protein structure, pathology and physiology.
Jentsch TJ. (2008)
30 more

2 mentions without citation

Intracellular β-nicotinamide adenine dinucleotide inhibits the skeletal muscle ClC-1 chloride channel.
Bennetts et al. (2012)
1 more