› 2j8o

X-ray diffraction
2.49Å resolution

Structure of the immunoglobulin tandem repeat of titin A168-A169

Released:
DOI: 10.2210/pdb2j8o/pdb
PDB entry 2j8o coloured by chain, front view.
PDB entry 2j8o coloured by chain, side view.
PDB entry 2j8o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin.
Müller S, Lange S, Gautel M, Wilmanns M
J Mol Biol 371 469-80 (2007)
PMID: 17574571

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186809 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Titin Chains: A, B
Molecule details ›
Chains: A, B
Length: 197 amino acids
Theoretical weight: 21.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WZ42 (Residues: 31853-32047; Coverage: 1%)
Gene name: TTN
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: C222
Unit cell:
a: 95.56Å b: 122.487Å c: 98.699Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.252 0.249 0.3
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Muscle giants: molecular scaffolds in sarcomerogenesis.
Kontrogianni-Konstantopoulos et al. (2009)
7 more

2 mentions without citation

Pairwise sequence similarity mapping with PaSiMap: Reclassification of immunoglobulin domains from titin as case study.
Su et al. (2022)
1 more