› 2i8n

Solution NMR

Solution structure of the second bromodomain of Brd4

Released:
DOI: 10.2210/pdb2i8n/pdb
PDB entry 2i8n coloured by chain, ensemble of 20 models, front view.
PDB entry 2i8n coloured by chain, ensemble of 20 models, side view.
PDB entry 2i8n coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Liu Y, Wu JH, Shi YY

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 13.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 352-457; Coverage: 8%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Distance geometry simulated annealing molecular dynamics torsion angle dynamics
Expression system: Escherichia coli

Quick links