› 2i0b

X-ray diffraction
1.96Å resolution

Crystal structure of the GluR6 ligand binding core ELKQ mutant dimer at 1.96 Angstroms Resolution

Released:
DOI: 10.2210/pdb2i0b/pdb
PDB entry 2i0b coloured by chain, front view.
PDB entry 2i0b coloured by chain, side view.
PDB entry 2i0b coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Conformational restriction blocks glutamate receptor desensitization.
Weston MC, Schuck P, Ghosal A, Rosenmund C, Mayer ML
Nat Struct Mol Biol 13 1120-7 (2006)
PMID: 17115050

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154585 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 259 amino acids
Theoretical weight: 29.37 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P42260 (Residues: 429-544, 667-806; Coverage: 29%)
Gene names: Glur6, Grik2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand GLU 3 x GLU
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43212
Unit cell:
a: 94.215Å b: 94.215Å c: 219.836Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.172 0.211
Expression system: Escherichia coli

Quick links

Citations

18 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
17 more

1 mention without citation

Selectivity and cooperativity of modulatory ions in a neurotransmitter receptor.
Vijayan et al. (2009)