› 2hjw

X-ray diffraction
2.5Å resolution

Crystal Structure of the BC domain of ACC2

Released:
DOI: 10.2210/pdb2hjw/pdb
PDB entry 2hjw coloured by chain, front view.
PDB entry 2hjw coloured by chain, side view.
PDB entry 2hjw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the biotin carboxylase domain of human acetyl-CoA carboxylase 2.
Cho YS, Lee JI, Shin D, Kim HT, Cheon YH, Seo CI, Kim YE, Hyun YL, Lee YS, Sugiyama K, Park SY, Ro S, Cho JM, Lee TG, Heo YS
Proteins 70 268-72 (2008)
PMID: 17876819

Function and Biology Details

Reaction catalysed: 
ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126388 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetyl-CoA carboxylase 2 Chain: A
Molecule details ›
Chain: A
Length: 573 amino acids
Theoretical weight: 63.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O00763 (Residues: 216-775; Coverage: 23%)
Gene names: ACACB, ACC2, ACCB
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P3221
Unit cell:
a: 75.797Å b: 75.797Å c: 189.006Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.251 0.212 0.248
Expression system: Escherichia coli BL21

Quick links

Citations

5 review citations

Structure and function of biotin-dependent carboxylases.
Tong L. (2013)
4 more

1 mention without citation

GWOVina: A grey wolf optimization approach to rigid and flexible receptor docking.
Wong et al. (2021)