› 2hjf

X-ray diffraction
2.9Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-209453 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Antibody fragment Heavy chain Chain: A
Molecule details ›
Chain: A
Length: 219 amino acids
Theoretical weight: 23.41 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Antibody fragment Light chain Chain: B
Molecule details ›
Chain: B
Length: 212 amino acids
Theoretical weight: 23.44 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
pH-gated potassium channel KcsA Chain: C
Molecule details ›
Chain: C
Length: 103 amino acids
Theoretical weight: 10.98 KDa
Source organism: Streptomyces lividans
UniProt:
  • Canonical: P0A334 (Residues: 22-124; Coverage: 64%)
Gene names: kcsA, skc1
Sequence domains: Ion channel
Structure domains: Helix Hairpins

Ligands and Environments

2 bound ligands:
Ligand K 4 x K
Ligand TBA 1 x TBA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: I4
Unit cell:
a: 156.2Å b: 156.2Å c: 76.316Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.225 0.284

Quick links

Citations

3 review citations

K+ channel modulators for the treatment of neurological disorders and autoimmune diseases.
Wulff et al. (2008)
2 more

2 mentions without citation

Crystallization chaperone strategies for membrane proteins.
Lieberman et al. (2011)
1 more