› 2hfh

Solution NMR

THE NMR STRUCTURES OF A WINGED HELIX PROTEIN: GENESIS, 20 STRUCTURES

Released:
DOI: 10.2210/pdb2hfh/pdb
PDB entry 2hfh coloured by chain, ensemble of 20 models, front view.
PDB entry 2hfh coloured by chain, ensemble of 20 models, side view.
PDB entry 2hfh coloured by chain, ensemble of 20 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural changes in the region directly adjacent to the DNA-binding helix highlight a possible mechanism to explain the observed changes in the sequence-specific binding of winged helix proteins.
Marsden I, Jin C, Liao X
J Mol Biol 278 293-9 (1998)
PMID: 9571051

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179004 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Forkhead box protein D3 Chain: A
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 13.05 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q63245 (Residues: 1-101; Coverage: 100%)
Gene names: Foxd3, Hfh2
Sequence domains: Forkhead domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DIANA
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Forkhead transcription factors: key players in development and metabolism.
Carlsson et al. (2002)
11 more

5 mentions without citation

Overview of protein structural and functional folds.
Sun et al. (2004)
4 more