› 2hes

X-ray diffraction
1.7Å resolution

Cytosolic Iron-sulphur Assembly Protein- 1

Released:
DOI: 10.2210/pdb2hes/pdb
PDB entry 2hes coloured by chain, front view.
PDB entry 2hes coloured by chain, side view.
PDB entry 2hes coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis.
Srinivasan V, Netz DJ, Webert H, Mascarenhas J, Pierik AJ, Michel H, Lill R
Structure 15 1246-57 (2007)
PMID: 17937914

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170220 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytosolic iron-sulfur protein assembly protein 1 Chain: X
Molecule details ›
Chain: X
Length: 330 amino acids
Theoretical weight: 37.32 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q05583 (Residues: 1-330; Coverage: 100%)
Gene names: CIA1, YDR267C
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 35.211Å b: 70.026Å c: 130.366Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.224 0.275
Expression system: Escherichia coli

Quick links

Citations

18 review citations

Function and biogenesis of iron-sulphur proteins.
Lill R. (2009)
17 more

2 mentions without citation

The WD40 domain is required for LRRK2 neurotoxicity.
Jorgensen et al. (2009)
1 more