› 2he0

X-ray diffraction
1.9Å resolution

Crystal structure of a human Notch1 ankyrin domain mutant

Released:
DOI: 10.2210/pdb2he0/pdb
PDB entry 2he0 coloured by chain, front view.
PDB entry 2he0 coloured by chain, side view.
PDB entry 2he0 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Gupta D, Ehebauer MT, Chirgadze DY, Martinez Arias A, Blundell TL

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155484 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Notch 1 intracellular domain Chains: A, B
Molecule details ›
Chains: A, B
Length: 253 amino acids
Theoretical weight: 27.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46531 (Residues: 1872-2116; Coverage: 10%)
Gene names: NOTCH1, TAN1
Sequence domains:
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

1 bound ligand:
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P65
Unit cell:
a: 96.982Å b: 96.982Å c: 108.719Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.19 0.188 0.231
Expression system: Escherichia coli

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