2h14

X-ray diffraction
1.48Å resolution

Crystal of WDR5 (apo-form)

Released:
Source organism: Homo sapiens
Primary publication:
Molecular recognition of histone H3 by the WD40 protein WDR5.
Nat Struct Mol Biol 13 698-703 (2006)
PMID: 16829960

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-158474 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
WD repeat-containing protein 5 Chain: A
Molecule details ›
Chain: A
Length: 317 amino acids
Theoretical weight: 34.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 22-334; Coverage: 94%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: C2221
Unit cell:
a: 78.76Å b: 98.06Å c: 80.79Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.157 0.197
Expression system: Escherichia coli