› 2h0b

X-ray diffraction
2.1Å resolution

Crystal Structure of the second LNS/LG domain from Neurexin 1 alpha

Released:
DOI: 10.2210/pdb2h0b/pdb
PDB entry 2h0b coloured by chain, front view.
PDB entry 2h0b coloured by chain, side view.
PDB entry 2h0b coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Crystal structure of the second LNS/LG domain from neurexin 1alpha: Ca2+ binding and the effects of alternative splicing.
Sheckler LR, Henry L, Sugita S, Südhof TC, Rudenko G
J Biol Chem 281 22896-905 (2006)
PMID: 16772286

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173308 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurexin-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 184 amino acids
Theoretical weight: 20.35 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q28146 (Residues: 295-491; Coverage: 12%)
Gene name: NRXN1
Sequence domains: Laminin G domain
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand CA 4 x CA
Ligand GOL 4 x GOL
1 modified residue:
Ligand MSE 16 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F2
Spacegroup: P1
Unit cell:
a: 60.032Å b: 61.586Å c: 66.64Å
α: 78.47° β: 78.74° γ: 84.68°
R-values:
R R work R free
0.186 0.184 0.233
Expression system: Escherichia coli BL21(DE3)

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Citations

8 review citations

Neurexin-neuroligin signaling in synapse development.
Craig et al. (2007)
7 more

12 mentions without citation

Neurexins - versatile molecular platforms in the synaptic cleft.
Rudenko G. (2019)
11 more