› 2fwl

Solution NMR

Function and Biology Details

Reaction catalysed: 
4 ferrocytochrome c + O(2) + 8 H(+)(Side 1) = 4 ferricytochrome c + 4 H(2)O(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137473 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cytochrome c-552 Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 14.4 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli
UniProt:
  • Canonical: P04164 (Residues: 1-131; Coverage: 100%)
Gene name: cycA
Sequence domains: Cytochrome c
Structure domains: Cytochrome c-like domain
Cytochrome c oxidase subunit 2 Chain: B
Molecule details ›
Chain: B
Length: 136 amino acids
Theoretical weight: 14.95 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli
UniProt:
  • Canonical: P98052 (Residues: 1-135; Coverage: 100%)
Gene names: cbaB, ctaC
Sequence domains: Cytochrome C oxidase subunit II, periplasmic domain
Structure domains: Cupredoxins - blue copper proteins

Ligands and Environments

2 bound ligands:
Ligand HEC 1 x HEC
Ligand CUA 1 x CUA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: docking calculations
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Thermus thermophilus as biological model.
Cava et al. (2009)
4 more

1 mention without citation

Alternative ground states enable pathway switching in biological electron transfer.
Abriata et al. (2012)