› 2etx

X-ray diffraction
1.33Å resolution

Crystal Structure of MDC1 Tandem BRCT Domains

Released:
DOI: 10.2210/pdb2etx/pdb
PDB entry 2etx coloured by chain, front view.
PDB entry 2etx coloured by chain, side view.
PDB entry 2etx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for the association of microcephalin (MCPH1) protein with the cell division cycle protein 27 (Cdc27) subunit of the anaphase-promoting complex.
Singh N, Wiltshire TD, Thompson JR, Mer G, Couch FJ
J Biol Chem 287 2854-62 (2012)
PMID: 22139841

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172077 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mediator of DNA damage checkpoint protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 209 amino acids
Theoretical weight: 22.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14676 (Residues: 1884-2089; Coverage: 10%)
Gene names: KIAA0170, MDC1, NFBD1
Sequence domains:
Structure domains: BRCT domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P1
Unit cell:
a: 41.89Å b: 44.35Å c: 63.1Å
α: 70.98° β: 86.45° γ: 61.91°
R-values:
R R work R free
0.201 0.202 0.226
Expression system: Escherichia coli

Quick links

Citations

8 review citations

MCPH1: a window into brain development and evolution.
Pulvers et al. (2015)
7 more

5 mentions without citation

Fast and anisotropic flexibility-rigidity index for protein flexibility and fluctuation analysis.
Opron et al. (2014)
4 more