› 2e8d

Solid-state NMR

3D Structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR

Released:
DOI: 10.2210/pdb2e8d/pdb
PDB entry 2e8d coloured by chain, ensemble of 10 models, front view.
PDB entry 2e8d coloured by chain, ensemble of 10 models, side view.
PDB entry 2e8d coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
3D structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR.
Iwata K, Fujiwara T, Matsuki Y, Akutsu H, Takahashi S, Naiki H, Goto Y
Proc Natl Acad Sci U S A 103 18119-24 (2006)
PMID: 17108084

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158378 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-2-microglobulin form pI 5.3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 22 amino acids
Theoretical weight: 2.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 40-61; Coverage: 22%)
Gene names: B2M, CDABP0092, HDCMA22P

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 50%
Expression system: Escherichia coli

Quick links

Citations

31 review citations

Functional amyloid--from bacteria to humans.
Fowler et al. (2007)
30 more

9 mentions without citation

K3 fragment of amyloidogenic beta(2)-microglobulin forms ion channels: implication for dialysis related amyloidosis.
Mustata et al. (2009)
8 more