› 2dpk

X-ray diffraction
2.5Å resolution

The Crystal Structure of the Primary Ca2+ Sensor of the Na+/Ca2+ Exchanger

Released:
DOI: 10.2210/pdb2dpk/pdb
PDB entry 2dpk coloured by chain, front view.
PDB entry 2dpk coloured by chain, side view.
PDB entry 2dpk coloured by chain, top view.
Source organism: Canis lupus familiaris
Primary publication:
The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif.
Nicoll DA, Sawaya MR, Kwon S, Cascio D, Philipson KD, Abramson J
J Biol Chem 281 21577-21581 (2006)
PMID: 16774926

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150039 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium/calcium exchanger 1 Chain: A
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 16.69 KDa
Source organism: Canis lupus familiaris
Expression system: Escherichia coli
UniProt:
  • Canonical: P23685 (Residues: 402-541; Coverage: 15%)
Gene names: NCX1, SLC8A1
Sequence domains: Calx-beta domain
Structure domains: Immunoglobulin-like

Ligands and Environments

3 bound ligands:
Ligand CA 4 x CA
Ligand GAI 1 x GAI
Ligand EPE 1 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P21212
Unit cell:
a: 59.624Å b: 45.524Å c: 57.269Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.222 0.284
Expression system: Escherichia coli

Quick links

Citations

13 review citations

The SLC8 gene family of sodium-calcium exchangers (NCX) - structure, function, and regulation in health and disease.
Khananshvili D. (2013)
12 more

17 mentions without citation

Ca2+ regulation of ion transport in the Na+/Ca2+ exchanger.
Hilge M. (2012)
16 more