› 2d58

X-ray diffraction
1.9Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157146 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Allograft inflammatory factor 1 Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 12.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55008 (Residues: 17-123; Coverage: 73%)
Gene names: AIF1, G1, IBA1
Sequence domains: Allograft inflammatory factor 1

Ligands and Environments

1 bound ligand:
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: C2
Unit cell:
a: 60.748Å b: 36.617Å c: 44.024Å
α: 90° β: 99.71° γ: 90°
R-values:
R R work R free
0.195 0.195 0.249
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Targeting microglia L-type voltage-dependent calcium channels for the treatment of central nervous system disorders.
Hopp SC. (2021)
1 more

3 mentions without citation

Microglia Specific Drug Targeting Using Natural Products for the Regulation of Redox Imbalance in Neurodegeneration.
Maurya et al. (2021)
2 more