2d4h

X-ray diffraction
2.9Å resolution

Crystal-structure of the N-terminal large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with GMP

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-152319 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Guanylate-binding protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 328 amino acids
Theoretical weight: 37.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P32455 (Residues: 1-317; Coverage: 54%)
Gene name: GBP1
Sequence domains: Guanylate-binding protein, N-terminal domain
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P21
Unit cell:
a: 39.921Å b: 173.45Å c: 49.632Å
α: 90° β: 110.85° γ: 90°
R-values:
R R work R free
0.235 0.233 0.275
Expression system: Escherichia coli BL21