› 2cy7

X-ray diffraction
1.9Å resolution

The crystal structure of human Atg4B

Released:
DOI: 10.2210/pdb2cy7/pdb
PDB entry 2cy7 coloured by chain, front view.
PDB entry 2cy7 coloured by chain, side view.
PDB entry 2cy7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy.
Sugawara K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F
J Biol Chem 280 40058-65 (2005)
PMID: 16183633

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195248 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cysteine protease ATG4B Chain: A
Molecule details ›
Chain: A
Length: 396 amino acids
Theoretical weight: 44.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y4P1 (Residues: 1-393; Coverage: 100%)
Gene names: APG4B, ATG4B, AUTL1, KIAA0943
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2221
Unit cell:
a: 51.913Å b: 88.339Å c: 160.139Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.215 0.247
Expression system: Escherichia coli

Quick links

Citations

23 review citations

The machinery of macroautophagy.
Feng et al. (2014)
22 more

20 mentions without citation

Autophagy-regulating protease Atg4: structure, function, regulation and inhibition.
Maruyama et al. (2017)
19 more