Function and Biology Details
Reaction catalysed:
(1a) a [histone H3]-N(6),N(6)-dimethyl-L-lysine(4) + acceptor + H(2)O = a [histone H3]-N(6)-methyl-L-lysine(4) + formaldehyde + reduced acceptor
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Lysine-specific histone demethylase 1A (preferred)
PDBe Complex ID:
PDB-CPX-129945 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysine-specific histone demethylase 1A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 13.73 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: SWIRM domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Length: 124 amino acids
Theoretical weight: 13.73 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical:
O60341 (Residues: 169-279; Coverage: 13%)
Sequence domains: SWIRM domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Refinement method:
torsion angle dynamics
Expression system: Not provided
