› 2c2h

X-ray diffraction
1.85Å resolution

CRYSTAL STRUCTURE OF THE HUMAN RAC3 IN COMPLEX WITH GDP

Released:
DOI: 10.2210/pdb2c2h/pdb
PDB entry 2c2h coloured by chain, front view.
PDB entry 2c2h coloured by chain, side view.
PDB entry 2c2h coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Debreczeni JE, Yang X, Zao Y, Elkins J, Gileadi C, Burgess N, Colebrook S, Gileadi O, Fedorov O, Bunkoczi G, von Delft F, Doyle D, Sundstrom M, Arrowsmith C, Weigelt J, Edwards A

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158088 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related C3 botulinum toxin substrate 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 192 amino acids
Theoretical weight: 21.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P60763 (Residues: 1-192; Coverage: 100%)
Gene name: RAC3
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

4 bound ligands:
Ligand GDP 9 x GDP
Ligand CA 12 x CA
Ligand SO4 4 x SO4
Ligand MG 5 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: R3
Unit cell:
a: 110.32Å b: 110.32Å c: 81.79Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.194 0.229
Expression system: Escherichia coli BL21

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