› 2bzy

X-ray diffraction
2.5Å resolution

Homodimer of CrkL-SH3C domain

Released:
DOI: 10.2210/pdb2bzy/pdb
PDB entry 2bzy coloured by chain, front view.
PDB entry 2bzy coloured by chain, side view.
PDB entry 2bzy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The C-terminal SH3 domain of CRKL as a dynamic dimerization module transiently exposing a nuclear export signal.
Harkiolaki M, Gilbert RJ, Jones EY, Feller SM
Structure 14 1741-53 (2006)
PMID: 17161365

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155437 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Crk-like protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 67 amino acids
Theoretical weight: 7.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46109 (Residues: 237-303; Coverage: 22%)
Gene name: CRKL
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P6122
Unit cell:
a: 71.317Å b: 71.317Å c: 146.428Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.263 0.263 0.309
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Regulated unfolding of proteins in signaling.
Mitrea et al. (2013)
7 more

4 mentions without citation

Linking in domain-swapped protein dimers.
Baiesi et al. (2016)
3 more