› 2bou

X-ray diffraction
1.9Å resolution

EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with barium.

Released:
DOI: 10.2210/pdb2bou/pdb
PDB entry 2bou coloured by chain, front view.
PDB entry 2bou coloured by chain, side view.
PDB entry 2bou coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55.
Abbott RJ, Spendlove I, Roversi P, Fitzgibbon H, Knott V, Teriete P, McDonnell JM, Handford PA, Lea SM
J Biol Chem 282 22023-32 (2007)
PMID: 17449467

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193771 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adhesion G protein-coupled receptor E2 Chain: A
Molecule details ›
Chain: A
Length: 143 amino acids
Theoretical weight: 15.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UHX3 (Residues: 25-260; Coverage: 18%)
Gene names: ADGRE2, EMR2
Sequence domains: Calcium-binding EGF domain
Structure domains: Laminin

Ligands and Environments

3 bound ligands:
Ligand BA 2 x BA
Ligand CA 2 x CA
Ligand CAC 1 x CAC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21212
Unit cell:
a: 91.06Å b: 61.56Å c: 35.47Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.238 0.255
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets.
Tang et al. (2012)
10 more

9 mentions without citation

Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop.
Aykul et al. (2020)
8 more