› 2b9b

X-ray diffraction
2.85Å resolution

Structure of the Parainfluenza Virus 5 F Protein in its Metastable, Pre-fusion Conformation

Released:
DOI: 10.2210/pdb2b9b/pdb
PDB entry 2b9b coloured by chain, front view.
PDB entry 2b9b coloured by chain, side view.
PDB entry 2b9b coloured by chain, top view.
Source organism: Mammalian orthorubulavirus 5
Primary publication:
Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation.
Yin HS, Wen X, Paterson RG, Lamb RA, Jardetzky TS
Nature 439 38-44 (2006)
PMID: 16397490

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138210 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fusion glycoprotein F1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 497 amino acids
Theoretical weight: 53.55 KDa
Source organism: Mammalian orthorubulavirus 5
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P04849 (Residues: 20-477; Coverage: 89%)
Gene name: F
Sequence domains: Fusion glycoprotein F0
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 12 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 32-ID
Spacegroup: C2221
Unit cell:
a: 160.206Å b: 259.864Å c: 154.012Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.222 0.259
Expression system: Trichoplusia ni

Quick links

Citations

59 review citations

Viral membrane fusion.
Harrison SC. (2008)
58 more

46 mentions without citation

Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme.
White et al. (2008)
45 more