› 2b96

X-ray diffraction
1.7Å resolution

Third Calcium ion found in an inhibitor bound phospholipase A2

Released:
DOI: 10.2210/pdb2b96/pdb
PDB entry 2b96 coloured by chain, front view.
PDB entry 2b96 coloured by chain, side view.
PDB entry 2b96 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Third calcium ion found in an inhibitor-bound phospholipase A2.
Sekar K, Gayathri D, Velmurugan D, Jeyakanthan J, Yamane T, Poi MJ, Tsai MD
Acta Crystallogr D Biol Crystallogr 62 392-7 (2006)
PMID: 16552140

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132750 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phospholipase A2 Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 13.82 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00593 (Residues: 23-145; Coverage: 95%)
Gene name: PLA2G1B
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

4 bound ligands:
Ligand CA 3 x CA
Ligand CL 1 x CL
Ligand TRS 4 x TRS
Ligand ANN 1 x ANN
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3121
Unit cell:
a: 46.19Å b: 46.19Å c: 102.86Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.202 0.221
Expression system: Escherichia coli

Quick links

Citations

1 mention without citation

Ellagic Acid, Kaempferol, and Quercetin from Acacia nilotica: Promising Combined Drug With Multiple Mechanisms of Action.
Al-Nour et al. (2019)