› 2ab9

Solution NMR

Discovery, structural determination and processing of the precursor protein that produces the cyclic trypsin inhibitor SFTI-1

Released:
DOI: 10.2210/pdb2ab9/pdb
PDB entry 2ab9 coloured by chain, ensemble of 20 models, front view.
PDB entry 2ab9 coloured by chain, ensemble of 20 models, side view.
PDB entry 2ab9 coloured by chain, ensemble of 20 models, top view.
Source organism: Helianthus annuus
Primary publication:
Discovery, structural determination, and putative processing of the precursor protein that produces the cyclic trypsin inhibitor sunflower trypsin inhibitor 1.
Mulvenna JP, Foley FM, Craik DJ
J Biol Chem 280 32245-53 (2005)
PMID: 16036912

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175541 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trypsin inhibitor 1 Chain: A
Molecule details ›
Chain: A
Length: 31 amino acids
Theoretical weight: 3.37 KDa
Source organism: Helianthus annuus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4GWU5 (Residues: 26-56; Coverage: 100%)
Gene name: sfti1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, simulated annealing
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The cyclotide family of circular miniproteins: nature's combinatorial peptide template.
Craik et al. (2006)
4 more

2 mentions without citation

Intrinsic Disorder and Posttranslational Modifications: The Darker Side of the Biological Dark Matter.
Darling et al. (2018)
1 more