› 2ab6

X-ray diffraction
2.5Å resolution

HUMAN GLUTATHIONE S-TRANSFERASE M2-2 (E.C.2.5.1.18) complexed with S-METHYLGLUTATHIONE

Released:
DOI: 10.2210/pdb2ab6/pdb
PDB entry 2ab6 coloured by chain, front view.
PDB entry 2ab6 coloured by chain, side view.
PDB entry 2ab6 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Patskovsky Y, Almo SC, Listowsky I

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151172 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase Mu 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 217 amino acids
Theoretical weight: 25.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P28161 (Residues: 2-218; Coverage: 100%)
Gene names: GST4, GSTM2
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GSM 4 x GSM
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 56.12Å b: 76.716Å c: 212.449Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.252 0.229 0.28
Expression system: Escherichia coli BL21(DE3)

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